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KMID : 0604520220480020169
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Journal of the Society of Cosmetic Scientists of Korea
2022 Volume.48 No. 2 p.169 ~ p.180
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Hair Revitalization Effects of Streptococcus sp. Strain Culture Medium Filtrate (HAIRCLETM)
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Park Hye-Rim
Kim Ha-Yeon
Kim Jin-Young
Oh Sin-Seok
Kang Pil-Sun
Lee Gang-Hyuk
Lim Jung-Hyurk
Shin Song-Seok
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Abstract
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Streptococcus sp. is generally known as a strain that produces hyaluronic acid. In this study, we focused on ingredients other than hyaluronic acid among several metabolites produced by Streptococcus sp. during cultivation. The hair experimental sample (HAIRCLETM) was prepared with Streptococcus sp. culture filtrate under the condition that hyaluronic acid was not produced and the effect on the hair was identified. Tensile strength of hair was tested with a universal testing machine (UTM). Surface properties of a hair were examined with an atomic force microscope (AFM). Our results suggest that HAIRCLETM could prevent damage to a hair such as destroyed-cuticle, increased-faction force, and broken-hair. Furthermore, hair-related experiments confirmed that HAIRCLETM could promote the expression of hair growth factors VEGF, HGF, and Wnt10b and mitigate male hair loss by inhibiting androgen receptors and TGF-β2 expression. In addition, it was confirmed that the expression of barrier-related factors (INV, CLDN-1) was increased for oxidative stress, and the COX-2 expression, an inflammatory factor, was inhibited, thereby improving damaged scalp barriers and alleviating induced inflammation.
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KEYWORD
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Streptococcus sp. strain culture medium filtrate, hair revitalization, tensile strength, atomic force microscope, hair growth
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